From Boston/Cambridge
Take Mass Turnpike (Interstate 90) West to Rte 128/Interstate 95 interchange (exit 15).
Follow signs to Rte 128/95 South toward Needham, Providence, Cape Cod
Exit at Exit 19A onto Highland Avenue toward Newton Highlands
Take first turn past highway entrance onto First Avenue.  
250 First Avenue is .3 miles down on the left.

From West of Boston (Hartford, Western suburbs, etc.)
Take Mass Turnpike (Interstate 90) East to Rte 128/Interstate 95 interchange (exit 15).
Follow signs to Rte 128/95 South toward Needham, Westwood, Providence RI, Cape Cod
Exit at Exit 19A onto Highland Avenue toward Newton Highlands
Take first turn past highway entrance onto First Avenue.  
250 First Avenue is .3 miles down on the left.

From South of Boston (Providence, Cape Cod, Westwood, etc)
Follow signs to Rte 128/95 North toward Waltham, Manchester NH, Portsmouth NH, etc.
Exit at Exit 19A onto Highland Avenue toward Newton Highlands
Take first right turn from Highland Avenue onto First Avenue.  
250 First Avenue is .3 miles down on the left.

From North of Boston (Waltham, Lexington, New Hampshire, etc.)
Follow signs to Rte 128/95 South toward Needham, Westwood, Providence RI, Cape Cod
Exit at Exit 19A onto Highland Avenue toward Newton Highlands
Take first turn past highway entrance onto First Avenue.  
250 First Avenue is .3 miles down on the left.