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Project Leadership
This project will be led by Ernie Bush, Ph.D., Vice President & Scientific Director., Director of New Initiatives and Head of the Pre-Clinical Safety Projects, with project implementation management by Frank Attardo. Substantial contribution to this project shall also be made by Gene Williams, CEO and Andrew Branca, SVP, and supporting analyst staff as selected by CHA over the course of the project.

Dr. Bush has spent over 23 years working in the field of biomedical R&D most of which working in preclinical safety departments for major pharmaceutical companies.is CHA’s head and resident expert in the area pre-clinical drug safety. Ernie serves as Scientific Director on our multi-client, collaborative projects, serving as a liaison and facilitator. Ernie has spent over 23 years working in the field, most recently leading the Non-Clinical Drug Safety Department at F. Hoffman La Roche From 1992 to 2005 he worked at Hoffmann-La Roche, Inc. and for the last 5 years of that time he led their Non-Clinical Drug Safety Department. This department of approximately 120 members was comprised of the following functional groups: Drug Metabolism, Non-Clinical Pharmacokinetics, Bioanalytical, Toxicology (including Safety Pharmacology and Teratology), and Pathology. The scope of their responsibilities spanned from early Discovery support through to NDA with particular emphasis on providing an integrated safety assessment to projects across all phases of Discovery and Development. Although Dr. Bush’s graduate training and early career focused on bioanalytics and drug metabolism, he has always had a special interest in how pharma safety data was collected, managed and interpreted; this interest has evolved into a major job function due in part to the exploding volume of safety data generated in today’s R&D environment. Consequently, Dr. Bush has been asked to lead several global initiatives on safety information management practices, including a global safety LIMS system at Roche and a global information repository for toxicogenomics data for the International Life Sciences Institute (ILSI). His in-depth knowledge and broad experience in both the informatics and safety assessment fields has made him a unique leader in today’s complex drug development landscape. Ernie can be reached by email or 781-320-4018.

Frank Attardo, Project Director
Mr. Attardo has over 25 years experience in the areas of operations management, strategic planning, and process improvement. Frank spent 18 years in the Hewlett Packard organization, most recently as Medical Products Group – Manufacturing Operations Manager.  He has broad experience in the planning and execution of numerous change management initiatives. You can contact Frank by email or 781-320-4015.

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