Ernie Bush, PhD 

Scientific Director 

Dr. Ernie Bush is CHA's leader and expert in preclinical drug safety. Ernie serves as Scientific Director on our multi-client, collaborative projects, acting as liaison and facilitator.  

Ernie has spent over 23 years working in the field of biomedical R&D, the majority of time spent working in preclinical safety departments for major pharmaceutical companies. From 1992 to 2005 he worked at Hoffmann-La Roche and for five years led their Non-Clinical Drug Safety Department of 120 members including Drug Metabolism, Non-Clinical Pharmacokinetics, Bioanalytical, Toxicology (including Safety Pharmacology and Teratology) and Pathology funcional groups. The scope of their responsibilities spanned from early Discovery support through NDA with particular emphasis on providing an integrated safety assessment to projects across all phases of Discovery and Development. 

Ernie has been asked to lead several global initiatives on safety information management practices, including a global safety LIMS system at Roche and a global information repository for toxicogenomics data for the International Life Sciences Institute (ILSI). His in-depth knowledge and broad experience in both the informatics and safety assessment fields has made him a unique leader in today’s complex drug development landscape.